In the Mail System menu, the email flow is configured by the SEPPmail Secure E-Mail Gateway.
To ensure that the SEPPmail Secure E-Mail Gateway does not accept any unsecured connections, additionally, the option Require TLS encryption (see SMTP settings) is to be activated.
The systems which may transmit emails to unknown recipients via the SEPPmail Secure E-Mail Gateway (Relaying) must be indicated. For all Office365 servers, this can be set comfortably via the option
Allow relaying for Exchange Online servers
(see Exchange Online Relaying).

All further settings are to be made individually for each Managed Domain.